ER Quality Control: The Cytoplasmic Connection
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چکیده
منابع مشابه
ER Quality Control: The Cytoplasmic Connection
unfolded substrate into the active site. Proteasomes The endoplasmic reticulum (ER) is the port of entry of are abundant in the cytoplasm and nucleus, but are membrane and secretory proteins into the central vacuapparently absent from the ER lumen. olar system, which includes the ER itself, the Golgi appaMutations in the cystic fibrosis transmembrane conratus, lysosomes, endosomes, the plasma m...
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Protein maturation in the endoplasmic reticulum (ER) is subject to stringent quality control. Terminally misfolded polypeptides are usually ejected into the cytoplasm and targeted for destruction by the proteasome. Ubiquitin conjugation is essential for both extraction and proteolysis. We discuss the role of the ubiquitin conjugation machinery in this pathway and focus on the role of ubiquitin ...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81881-4